We are a team of scientists working to better understand immunity at our mucosal surfaces.
The Langel Research Team is located in the Center for Global Health and Diseases and Department of Pathology at Case Western Reserve University School of Medicine in Cleveland, Ohio.
Human-milk transfer of maternal immunity from Langel et al., Cell Host & Microbe 2022. Immunomodulatory breast-milk components including secretory IgA and IgG passively transfer into milk to protect and regulate the infant intestinal tract.
The Langel Research Team uses multi-disciplinary approaches to study mucosal immune responses against viral infections.
We are focused on better understanding the role of antibodies and antibody-producing plasma cells during disease, with a special emphasis on maternal & pediatric populations (moms & babies).
Our goal is to define correlates of mucosal immune protection against viral diseases to promote the development of mucosal vaccines against major human pathogens. The viruses we study include influenza, SARS-CoV-2, rotavirus, and norovirus.