We are a team of scientists working to better understand immunity at our mucosal surfaces.
The Langel Research Team is located in the Center for Global Health and Diseases and Department of Pathology at Case Western Reserve University School of Medicine in Cleveland, Ohio.
Human-milk transfer of maternal immunity from Langel et al., Cell Host & Microbe 2022. Immunomodulatory breast-milk components including secretory IgA and IgG passively transfer into milk to protect and regulate the infant intestinal tract.
The Langel Research Team uses multi-disciplinary approaches to study mucosal immune responses against viral infections.
We are focused on better understanding the role of antibodies and antibody-producing plasma cells during disease, with a special emphasis on maternal & pediatric populations (moms & babies).
Our goal is to define correlates of mucosal immune protection against viral diseases to promote the development of mucosal vaccines against major human pathogens. The viruses we study include influenza, SARS-CoV-2, rotavirus, and norovirus.
Langel Research Team News
1/20/2025
Pari Baker presented: Investigating the effects of intramammary inoculation of bovine-origin H5N1 influenza in lactating ferrets at the 2025 Conference of Research Workers in Animal Diseases
1/20/2025
Congratulations to Dr. Stephanie Langel on her recent publication: Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus
1/9/2025
Congratulations to post-doc Lauren Stewart Stafford on her recent publication: A peptide mimic of SOCS1 modulates equine peripheral immune cells in vitro and ocular effector functions in vivo: implications for recurrent uveitis
11/17/2024
Congratulations to lead authors Pari Baker and Michelle Moyer as well as the Langel Research Team for preprint publication of: Intramammary infection of bovine H5N1 influenza virus in ferrets leads to transmission and mortality in suckling neonates